ACE, ACE Inhibitors, and Other JNK

ACE, ACE inhibitors, and other JNK.

The renin-angiotensin system (RAS) plays a pivotal role in the regulation of blood pressure, volume homeostasis, vascular function, and cell growth. In what is considered the classic RAS, renin is released from juxtaglomerular cells of the kidney into the circulation where it converts angiotensinogen from the liver to angiotensin I. Angiotensin I is subsequently hydrolyzed by a peptidyl dipepti...

ACE inhibitors and anaesthesia.

During the last decade, two angiotensin converting enzyme (ACE) inhibitors, captopril and enalapril, have become accepted into clinical practice and are regarded as effective treatments for hypertension and congestive cardiac failure.' A third agent, lisinopril, had recently become available and others are likely to be introduced in the near future. It is clear, therefore, that more patients, w...

Chymase: the other ACE?

THE THERAPEUTIC USE OF angiotensin-converting enzyme (ACE) inhibitors has been an integral part of the standard of care for hypertension and related diseases for decades. While the beneficial effects of these drugs are universally appreciated, there are a variety of physiological anomalies that remind us that there is still much to be learned about the mechanisms involved in the observed therap...

eComment: Statins and ACE-inhibitors.

Ace Inhibitors: a Comprehensive Review

Hypertension is a chronic increase in blood pressure, characterized as primary and secondary hypertension. The disorder is associated with various risk factors like obesity, diabetes, age, lack of exercise etc. Hypertension is being treated since ancient times by Ayurvedic, Chinese and Unani medicine. Now various allopathic drugs are available which include diuretics, calcium channel blockers, ...